Rachel Brosnahan as Miriam "Midge" Maisel (née Weissman), an upper-middle class Jewish American housewife and mother who discovers her flair for stand-up comedy after husband Joel abruptly leaves her. Fashion-obsessed and hyper-competent, Midge is hired as a make-up counter girl at B. Altman and starts performing stand-up comedy in clubs across New York, eventually becoming a world-famous comedian.